4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3541-4. doi: 10.1016/j.bmcl.2008.05.015. Epub 2008 May 6.

Abstract

The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / genetics
  • Drug Design
  • Molecular Conformation
  • Oxazolidinones / chemical synthesis
  • Oxazolidinones / chemistry*
  • Oxazolidinones / pharmacology
  • RNA, Bacterial / drug effects*
  • RNA, Bacterial / genetics
  • RNA, Transfer / drug effects*
  • RNA, Transfer / genetics
  • Stereoisomerism
  • Terminator Regions, Genetic / drug effects
  • Terminator Regions, Genetic / genetics
  • Transcription, Genetic / drug effects
  • Transcription, Genetic / genetics

Substances

  • Anti-Bacterial Agents
  • Oxazolidinones
  • RNA, Bacterial
  • RNA, Transfer