Abstract
Liver fibrosis (LF) is the accumulation of extracellular matrix (ECM) proteins due to chronic liver injury. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to perform a comparative analysis of cytosolic and nuclear protein patterns of nontransgenic (NTg) and HBV transgenic (Tg) mice livers at early stages of fibrosis. We identified several candidate proteins, involved in a variety of pathways, which could be used as putative biomarkers for LF early detection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biomarkers / metabolism
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Cell Nucleus / metabolism
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Cytosol / metabolism
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Electrophoresis, Gel, Two-Dimensional
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Hepatitis B / complications*
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Keratins / metabolism
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Liver / metabolism*
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Liver / pathology
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Liver Cirrhosis / etiology
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Liver Cirrhosis / genetics
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Liver Cirrhosis / metabolism*
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Nuclear Proteins / metabolism
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Phosphorylation
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Proteome / metabolism*
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Superoxide Dismutase / biosynthesis
Substances
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Biomarkers
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Nuclear Proteins
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Proteome
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Keratins
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Superoxide Dismutase