Abstract
The bioavailability of a novel water-soluble inclusion complex of CoQ10, prepared in our laboratory was determined and compared with the bioavailability of commercially available oil-based form of CoQ10. Experimental work consisted of single dose comparative bioavailability study on seven beagle dogs, with a 14-day washout period between treatments. Identification and quantification of CoQ10 was done with HPLC-MS method using positive APCI ionization and SIM mode, M+ m/z 863.4. The bioavailability results confirm that the water-soluble formulation has nearly three times higher AUC(0-48 h), two times higher Cmax, and Tmax is shortened from 6 to 4 h.
MeSH terms
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Absorption
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Animals
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Area Under Curve
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Biological Availability
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Calibration
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Chemistry, Pharmaceutical
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Chromatography, High Pressure Liquid / instrumentation
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Chromatography, High Pressure Liquid / methods
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Chromatography, High Pressure Liquid / veterinary
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Cross-Over Studies
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Dogs
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Drug Stability
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Half-Life
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Mass Spectrometry / methods
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Mass Spectrometry / veterinary
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Metabolic Clearance Rate
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Methanol / chemistry
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Models, Molecular
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Quality Control
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Reference Standards
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Reproducibility of Results
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Sensitivity and Specificity
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Solubility
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Ubiquinone / analogs & derivatives*
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Ubiquinone / blood
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Ubiquinone / pharmacokinetics
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Vitamins / blood
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Vitamins / pharmacokinetics*
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Water / chemistry
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beta-Cyclodextrins / metabolism
Substances
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Vitamins
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beta-Cyclodextrins
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Water
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Ubiquinone
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coenzyme Q10
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betadex
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Methanol