Cisplatin and etoposide combination therapy for primary glial tumors: preliminary results

A Boiardi; A Silvani; I Milanesi; L Munari; C L Solero; M Botturi

doi:10.1007/BF02337611

Cisplatin and etoposide combination therapy for primary glial tumors: preliminary results

Ital J Neurol Sci. 1991 Feb;12(1):33-7. doi: 10.1007/BF02337611.

Authors

A Boiardi¹, A Silvani, I Milanesi, L Munari, C L Solero, M Botturi

Affiliation

¹ Istituto Nazionale Neurologico C. Besta, Milano.

PMID: 1849504
DOI: 10.1007/BF02337611

Abstract

In this preliminary trial we studied 29 patients with primary malignant glial tumors to investigate the effectiveness of cisplatin combined with etoposide on these tumors. Hyperfractionated radiation therapy was given in the course of chemotherapy. The time to tumor progression in these glioblastoma multiforme (GBM) patients encouraged us to continue this treatment in a phase III study.

Publication types

Clinical Trial
Comparative Study

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Astrocytoma / drug therapy*
Brain Neoplasms / drug therapy*
Carmustine / therapeutic use
Cisplatin / administration & dosage
Combined Modality Therapy
Etoposide / administration & dosage
Follow-Up Studies
Glioblastoma / drug therapy*
Glioma / drug therapy*
Glioma / radiotherapy
Humans
Middle Aged

Substances

Etoposide
Cisplatin
Carmustine