New pentacyclic triterpenes from Gypsophila oldhamiana and their biological evaluation as glycogen phosphorylase inhibitors

Chem Biodivers. 2008 May;5(5):751-7. doi: 10.1002/cbdv.200890071.

Abstract

The three new pentacyclic triterpenes 1-3 were isolated and elucidated from the roots of Gypsophila oldhamiana, together with seven known triterpenes (4-10). These triterpenes were evaluated for their glycogen phosphorylase inhibitory activity and preliminary structure-activity trends are suggested.

MeSH terms

  • Caryophyllaceae / chemistry*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Glycogen Phosphorylase / antagonists & inhibitors*
  • Glycogen Phosphorylase / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pentacyclic Triterpenes / chemistry*
  • Pentacyclic Triterpenes / pharmacology*

Substances

  • Enzyme Inhibitors
  • Pentacyclic Triterpenes
  • Glycogen Phosphorylase