Abstract
General features of signal transduction by G proteins and structural properties of G-protein-modulated calcium channels are described. Recent results on roles of beta gamma dimers in signal transduction, on the kinetic properties of Gi alpha subunits and structural diversity of Go alpha subunits are discussed, as are the background and current state of our knowledge of the modulation of calcium channels by G proteins.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Calcium Channels / chemistry
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Calcium Channels / genetics
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Calcium Channels / metabolism*
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GTP-Binding Proteins / chemistry
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GTP-Binding Proteins / genetics
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GTP-Binding Proteins / metabolism*
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Humans
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Molecular Sequence Data
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Molecular Structure
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Sequence Homology, Nucleic Acid
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Signal Transduction / physiology
Substances
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Calcium Channels
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GTP-Binding Proteins