Serial assessment of immune status by circulating CD8 effector T cell frequencies for posttransplant infectious complications

Clin Dev Immunol. 2008:2008:718386. doi: 10.1155/2008/718386.

Abstract

To clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. The posttransplant infection rates progressively increased from 29% in Group I to 64.3% in Group III recipients. The posttransplant immune status was compared with the pretransplant status, based on the measure (% difference) and its graphical form (scatter plot). In Groups I and II, both approaches showed a strong upward deviation from pretransplant status upon posttransplant infection, indicating an enhanced clearance of pathogens. In Group III, in contrast, both approaches showed a clear downward deviation from preoperative status, indicating deficient cytotoxicity. The % E difference and scatter plot can be used as a useful indicator of a posttransplant infectious complication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytotoxicity, Immunologic
  • Female
  • Humans
  • Immunologic Memory
  • Infections* / epidemiology
  • Infections* / etiology
  • Infections* / immunology
  • Infections* / mortality
  • Liver Transplantation / adverse effects*
  • Liver Transplantation / immunology*
  • Living Donors
  • Male
  • Middle Aged
  • Postoperative Complications* / epidemiology
  • Postoperative Complications* / etiology
  • Postoperative Complications* / immunology
  • Postoperative Complications* / mortality