Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects

Stefan Quasthoff; Claudia Möckel; Walter Zieglgänsberger; Wolfgang Schreibmayer

doi:10.1111/j.1527-3458.2008.00044.x

Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects

CNS Neurosci Ther. 2008 Summer;14(2):107-19. doi: 10.1111/j.1527-3458.2008.00044.x.

Authors

Stefan Quasthoff¹, Claudia Möckel, Walter Zieglgänsberger, Wolfgang Schreibmayer

Affiliation

¹ Department for Neurology, Medical University of Graz, Austria.

Abstract

Tolperisone, a piperidine derivative, is assigned to the group of centrally acting muscle relaxants and has been in clinical use now for decades. The review summarizes the known pharmacokinetics, pharmacodynamics, toxicology and side effects in humans and the clinical use of tolperisone. A future perspective for further exploration of this drug is given.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Clinical Trials as Topic
Humans
Hypnotics and Sedatives
Muscle Relaxants, Central / adverse effects
Muscle Relaxants, Central / metabolism
Muscle Relaxants, Central / pharmacokinetics
Muscle Relaxants, Central / pharmacology*
Muscle Relaxants, Central / toxicity
Tolperisone / adverse effects
Tolperisone / metabolism
Tolperisone / pharmacokinetics
Tolperisone / pharmacology*
Tolperisone / toxicity

Substances

Hypnotics and Sedatives
Muscle Relaxants, Central
Tolperisone