Regulation of gene expression by the RNA-binding protein Sam68 in cancer

Biochem Soc Trans. 2008 Jun;36(Pt 3):505-7. doi: 10.1042/BST0360505.

Abstract

Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasms / genetics*
  • RNA Processing, Post-Transcriptional
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / metabolism*
  • Transcription, Genetic

Substances

  • RNA-Binding Proteins