In vitro hepatoprotective compounds from Suaeda glauca

Arch Pharm Res. 2008 May;31(5):594-7. doi: 10.1007/s12272-001-1198-1. Epub 2008 May 15.

Abstract

Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-beta-D-galactoside (3), and quercetin 3-O-beta-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC(50) values of 72.7+/-6.2 and 117.2+/-10.5 microM, respectively. Silybin as a positive control showed an EC(50) value of 82.4+/-4.1 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular
  • Cell Line, Tumor
  • Chenopodiaceae*
  • Chlorogenic Acid / analogs & derivatives*
  • Chlorogenic Acid / chemistry
  • Chlorogenic Acid / isolation & purification
  • Chlorogenic Acid / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • Humans
  • Liver Neoplasms
  • Protective Agents / chemistry
  • Protective Agents / pharmacology*
  • Tacrine / toxicity

Substances

  • 3,5-dicaffeoylquinic acid methyl ester
  • Drugs, Chinese Herbal
  • Protective Agents
  • Chlorogenic Acid
  • Tacrine
  • 3,5-dicaffeoylquinic acid