Abstract
The newly synthesized water-soluble cyclodiphosphazane ligands and their gold(I) complexes inhibit HeLa cell proliferation by activating p53 protein and inducing apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects*
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Gold / chemistry*
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HeLa Cells
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Heterocyclic Compounds, 1-Ring / chemical synthesis*
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Heterocyclic Compounds, 1-Ring / chemistry
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Heterocyclic Compounds, 1-Ring / pharmacology*
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Humans
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Ligands
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Models, Molecular
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / chemistry
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Organophosphorus Compounds / pharmacology*
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Solubility
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Tumor Suppressor Protein p53 / drug effects
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Tumor Suppressor Protein p53 / metabolism
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Water / chemistry*
Substances
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Heterocyclic Compounds, 1-Ring
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Ligands
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Organometallic Compounds
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Organophosphorus Compounds
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Tumor Suppressor Protein p53
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Water
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Gold