Silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents

Edgars Abele; Kira Rubina; Ramona Abele; Olegs Dzenitis; Pavel Arsenyan; Juris Popelis; Maris Veveris; Dainuvite Meirena; Edmunds Lukevics

doi:10.1155/MBD.2002.307

Silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents

Met Based Drugs. 2002;8(6):307-13. doi: 10.1155/MBD.2002.307.

Authors

Edgars Abele¹, Kira Rubina, Ramona Abele, Olegs Dzenitis, Pavel Arsenyan, Juris Popelis, Maris Veveris, Dainuvite Meirena, Edmunds Lukevics

Affiliation

¹ Latvian Institute of Organic Synthesis 21 Aizkraukles street Riga LV-1006 Latvia.

Abstract

Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.