Development of Acid-Sensitive Platinum(II) Complexes With Protein-Binding Properties

M T Schütte; R Mülhaupt; F Kratz

doi:10.1155/MBD.2000.89

Development of Acid-Sensitive Platinum(II) Complexes With Protein-Binding Properties

Met Based Drugs. 2000;7(2):89-100. doi: 10.1155/MBD.2000.89.

Authors

M T Schütte¹, R Mülhaupt, F Kratz

Affiliation

¹ Institute of Macromolecular Chemistry University of Freiburg Stefan-Meier-Straße 31 Freiburg 79104 Germany.

Abstract

Four new protein-binding platinum(II) complexes, 10, 11, 21, 22, in which the dichloroplatinum moiety is coordinated either to a carbon-substituted or a nitrogen-substituted ethylene diamino ligand, were prepared in ten-step syntheses. According to pH-dependent stability studies with strictly related compounds, 11 and 22 exhibit acid-sensitive properties.