Cytotoxic necrotizing factor 1 (CNF1) induces an inflammatory response in the urinary tract in vitro but not in vivo

Olof Hertting; Milan Chromek; Zuzana Slamová; Lavinia Kádas; Maja Söderkvist; Inga Vainumäe; Tiina Tallvik; Stefan H Jacobson; Annelie Brauner

doi:10.1016/j.toxicon.2008.03.019

Cytotoxic necrotizing factor 1 (CNF1) induces an inflammatory response in the urinary tract in vitro but not in vivo

Toxicon. 2008 Jun 15;51(8):1544-7. doi: 10.1016/j.toxicon.2008.03.019. Epub 2008 Mar 26.

Authors

Olof Hertting¹, Milan Chromek, Zuzana Slamová, Lavinia Kádas, Maja Söderkvist, Inga Vainumäe, Tiina Tallvik, Stefan H Jacobson, Annelie Brauner

Affiliation

¹ Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.

PMID: 18471840
DOI: 10.1016/j.toxicon.2008.03.019

Abstract

Cytotoxic necrotizing factor 1 (CNF1) is a well-defined virulence factor of uropathogenic Escherichia coli. We studied the role of CNF1 in uroepithelial cells as well as in children and adults with sporadic and recurrent UTI. Our study suggests that CNF1 may promote bacterial attachment and invasion and can induce an inflammatory response in the urinary tract in vitro but that its role in vivo is possibly minor in comparison with other virulence factors of the uropathogenic E. coli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Toxins / genetics
Cells, Cultured
Epithelial Cells / microbiology
Escherichia coli / genetics
Escherichia coli / pathogenicity*
Escherichia coli Proteins / genetics
Escherichia coli Proteins / physiology*
Humans
Mutation
Tissue Inhibitor of Metalloproteinase-1 / metabolism
Urinary Tract / microbiology*
Urinary Tract Infections / microbiology
Virulence Factors / genetics
Virulence Factors / physiology*

Substances

Bacterial Toxins
Escherichia coli Proteins
Tissue Inhibitor of Metalloproteinase-1
Virulence Factors
cytotoxic necrotizing factor type 1