On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel

Przemysław Borys; Zbigniew J Grzywna

doi:10.2478/s11658-008-0018-5

On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel

Cell Mol Biol Lett. 2008;13(4):526-34. doi: 10.2478/s11658-008-0018-5. Epub 2008 May 10.

Authors

Przemysław Borys¹, Zbigniew J Grzywna

Affiliation

¹ Department of Physical Chemistry and Technology of Polymers Section of Physics and Applied Mathematics, Silesian University of Technology, 44-100, Gliwice, Ks. M. Strzody 9, Poland. pborys@dione.cc

Abstract

We describe a new factor in the recovery from inactivation in the ball and chain model. We propose a model in which the tension from the chain may help pull the ball away from its binding site, reducing the duration of the inactivation period. A corresponding model was built and analysed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ion Channel Gating / physiology*
Models, Biological*
Models, Molecular
Potassium / metabolism
Protein Conformation*
Shaker Superfamily of Potassium Channels* / chemistry
Shaker Superfamily of Potassium Channels* / metabolism

Substances

Shaker Superfamily of Potassium Channels
Potassium