Trigeminal neuralgia is the most common facial pain syndrome,which remains a difficult condition to manage due to lack of knowledge on pathophysiological mechanisms. Local drug injection is a minimally invasive and useful technique to manage trigeminal neuralgia, with a high success rate and low incidence of morbidity. Although a large number of drugs have been used to treat trigeminal neuralgia, there still remains a great challenge to reduce the recurrent rates and complications both intra- or post- injections.