Background: Transformed cells of solid tumors often contain activators of fibrinolytic system allowing to create new metastatic centers. There are a few data of fibrinolytic potential of neoplastic cells of hematopoietic system. The aim was the evaluation of t-PA (tissue plasminogen activator) and PAI-1 (inhibitor of plasminogen activator type 1) in lymphocytes datained from patients with chronic lymphoid leukemia.
Investigated group: The study was performed in 35 patients with chronic lymphoid leukemia and in control group containing 20 healthy persons. From venous blood lymphocytes were isolated, calculated and homogenized using ultrasound disintegrator. In homogenates of cells and in the blood plasma concentrations of t-PA antigen (t-PA:Ag) and antigen of PAI-1 (PAI-1:Ag) were determined.
Results: In lymphocytes obtained from healthy persons more t-PA and PAI-1 was detected than in lymphocytes from patients with chronic lymphoid leukemia. In lymphocytes from patients PAI-1: Ag concentration was 14 fold higher than t-PA:Ag.
Conclusion: The lymphocytes of patients suffering from chronic lymphoid leukemia are different from healthy person in respect of t-PA:Ag and PAI-1:Ag concentration.