Nanoparticle assisted magnetic resonance imaging of the early reversible stages of amyloid beta self-assembly

Chem Commun (Camb). 2008 May 21:(19):2197-9. doi: 10.1039/b803294g. Epub 2008 Apr 11.

Abstract

Co@Pt-Au nanoparticles, which have enhanced magnetism and high stability in aqueous media, are utilized in conjunction with MRI to monitor the structural evolution of Abeta assemblies, especially Abeta protofibrils in the early reversible stages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / chemistry*
  • Amyloid beta-Peptides / metabolism
  • Cobalt / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Magnetics
  • Metal Nanoparticles / chemistry*
  • Peptide Fragments / chemistry*
  • Peptide Fragments / metabolism
  • Platinum / chemistry*

Substances

  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • Cobalt
  • Platinum