Microwave-enhanced sulphated zirconia and SZ/MCM-41 catalyzed regioselective synthesis of beta-amino alcohols under solvent-free conditions

Molecules. 2008 Apr 26;13(4):977-85. doi: 10.3390/molecules13040977.

Abstract

A solvent-free approach for the regioselective synthesis of beta-amino alcohols in shorter reaction times and higher yields, compared to conventional heating is described. It involves microwave (MW) exposure of undiluted reactants in the presence of sulphated zirconia (SZ) or sulphated zirconia over MCM-41 (SZM) as catalyst. Both acid materials can be easily recovered and reused.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Alcohols / chemical synthesis*
  • Amino Alcohols / chemistry
  • Catalysis
  • Chromatography, Gas
  • Ethylene Oxide / chemistry
  • Microwaves*
  • Silicon Dioxide / chemistry*
  • Solvents / chemistry*
  • Stereoisomerism
  • Sulfates / chemistry*
  • X-Ray Diffraction
  • Zirconium / chemistry*

Substances

  • Amino Alcohols
  • MCM-41
  • Solvents
  • Sulfates
  • Silicon Dioxide
  • Zirconium
  • Ethylene Oxide
  • zirconium oxide