Stereoselective one-pot synthesis of oxazolines

Saumen Hajra; Sukanta Bar; Debarshi Sinha; Biswajit Maji

doi:10.1021/jo8003937

Stereoselective one-pot synthesis of oxazolines

J Org Chem. 2008 Jun 6;73(11):4320-2. doi: 10.1021/jo8003937. Epub 2008 May 7.

Authors

Saumen Hajra¹, Sukanta Bar, Debarshi Sinha, Biswajit Maji

Affiliation

¹ Department of Chemistry, Indian Institute of Technology, Kharagpur, India. shajra@chem.iitkgp.ernet.in

PMID: 18459808
DOI: 10.1021/jo8003937

Abstract

Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields. The reaction is equally applicable to chalcones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclization
Magnetic Resonance Spectroscopy
Oxazoles / chemical synthesis*
Stereoisomerism

Substances

Oxazoles