High-resolution genotyping of Aspergillus fumigatus isolates recovered from chronically colonised patients with cystic fibrosis

Eur J Clin Microbiol Infect Dis. 2008 Oct;27(10):1005-7. doi: 10.1007/s10096-008-0527-1. Epub 2008 May 6.

Abstract

A series of 256 Aspergillus fumigatus isolates, recovered from eight patients with cystic fibrosis (CF), were genotyped using microsatellite-based typing. Only a limited number of genotypes were shared between patients and co-colonisation with multiple strains was indicated for all patients. Additionally, some genotypes were isolated recurrently, indicating that they are capable of prolonged colonisation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillosis / microbiology*
  • Aspergillus fumigatus / classification*
  • Aspergillus fumigatus / genetics*
  • Cluster Analysis
  • Cystic Fibrosis / complications*
  • DNA Fingerprinting
  • DNA, Fungal / genetics
  • Genotype
  • Humans
  • Microsatellite Repeats
  • Molecular Epidemiology
  • Mycological Typing Techniques

Substances

  • DNA, Fungal