Mammalian galectins: structure, carbohydrate specificity, and functions

E M Rapoport; O V Kurmyshkina; N V Bovin

doi:10.1134/s0006297908040032

Mammalian galectins: structure, carbohydrate specificity, and functions

Biochemistry (Mosc). 2008 Apr;73(4):393-405. doi: 10.1134/s0006297908040032.

Authors

E M Rapoport¹, O V Kurmyshkina, N V Bovin

Affiliation

¹ Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.

PMID: 18457568
DOI: 10.1134/s0006297908040032

Abstract

Galectins are a family of beta-galactoside binding lectins, homological by a sequence of the carbohydrate-binding site. In this review literature data about structure and carbohydrate specificity of galectins are discussed. The role of galectins in the regulation of cell adhesion in immune response, inflammation, and cancer progression is considered.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carbohydrate Metabolism
Carbohydrates / chemistry*
Galectins / chemistry*
Galectins / metabolism
Galectins / physiology*
Ligands
Mammals / metabolism
Membrane Proteins / physiology
Protein Structure, Tertiary

Substances

Carbohydrates
Galectins
Ligands
Membrane Proteins