Human mesenchymal stem cells as a stable source of VEGF-producing cells

J Tissue Eng Regen Med. 2008 Jun;2(4):184-9. doi: 10.1002/term.79.

Abstract

Vascular endothelial growth factor (VEGF) is a positive regulator and plays a crucial role in angiogenesis. We demonstrate that VEGF was highly expressed in cultures of human bone marrow-derived mesenchymal stem cells (hMSCs) and the high expression level was maintained during prolonged culture periods (checked up to passage 10). We also confirmed that in vivo hMSCs engrafted into immunodeficient mice could survive and secreted human VEGF. These findings suggest that implantation of hMSCs is a practical means as a source of VEGF production and might be effective in neoangiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Animals
  • Cytokines / metabolism
  • Female
  • Humans
  • Male
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism*
  • Mice
  • Mice, SCID
  • Neovascularization, Physiologic
  • Protein Array Analysis
  • Vascular Endothelial Growth Factor A / biosynthesis*

Substances

  • Cytokines
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A