Abstract
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Catechols / chemistry
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Catechols / isolation & purification
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Catechols / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Desiccation
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Dose-Response Relationship, Drug
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Fatty Alcohols / chemistry
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / pharmacology*
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Rhizome
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Zingiber officinale* / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Catechols
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Fatty Alcohols
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shogaol
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gingerol