Abstract
Adipocytes and osteoblasts are derived from mesenchymal stem cells, and some adipocyte differentiation regulators suppress osteoblast differentiation. PPAR-gammaplays a pivotal role for adipocyte differentiation and glucose tolerance. PPAR-gammais a member of nuclear receptor super family and regulates mRNA expression level of target genes by binding to fatty acid derivatives and thiazolidinediones. Recently, it was found that PPAR-gammainhibits osteoblast differentiation and regulates bone metabolism. In this report, we show recent studies about the extracellular signals regulating the transactivation function of PPAR-gamma.
MeSH terms
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Adaptor Proteins, Signal Transducing / physiology
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Adipocytes / cytology*
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Animals
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Bone and Bones / metabolism
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Calcium-Calmodulin-Dependent Protein Kinase Type 2 / physiology
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Cell Differentiation
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Humans
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MAP Kinase Kinase Kinases / physiology
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Mesenchymal Stem Cells / cytology
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Mice
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Osteoblasts / cytology*
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PPAR gamma / genetics*
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PPAR gamma / physiology*
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Signal Transduction / genetics*
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Signal Transduction / physiology*
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Transcriptional Activation
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Wnt Proteins / physiology
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Wnt-5a Protein
Substances
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Adaptor Proteins, Signal Transducing
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PPAR gamma
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Tab2 protein, mouse
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Wnt Proteins
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Wnt-5a Protein
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Wnt5a protein, mouse
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Wnt5a protein, rat
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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MAP Kinase Kinase Kinases
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MAP kinase kinase kinase 7