This paper uses remote sensing and geographic information systems (GIS); and descriptive statistics in the assessment of environmental change along the Savannah River Basin of Georgia. Results of the study show that Savannah River basin side of Georgia has been experiencing environmental change due to several decades of relentless pressure induced by anthropocentric activities and host of other socio-economic factors. Normalized Difference Vegetation Index (NDVI) analysis of the area also shows a decline in vegetation cover. The pace of ecological change showed some variations across time and space. Generally, the results point to a decline in water bodies, vegetation, and increase in population, loss of harvested cropland, farms and increasing threats to the environmental systems of the region.