Abstract
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aminoglycosides / chemistry*
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Animals
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Combinatorial Chemistry Techniques
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Diamines / blood
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Diamines / chemical synthesis*
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Diamines / pharmacology*
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Escherichia coli / drug effects
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Piperidines / blood
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Piperidines / chemical synthesis*
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Piperidines / pharmacology*
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Protein Biosynthesis / drug effects*
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Pseudomonas aeruginosa / drug effects*
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Structure-Activity Relationship
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Diamines
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Piperidines