Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3369-75. doi: 10.1016/j.bmcl.2008.04.023. Epub 2008 Apr 13.

Abstract

Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aminoglycosides / chemistry*
  • Animals
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Combinatorial Chemistry Techniques
  • Diamines / blood
  • Diamines / chemical synthesis*
  • Diamines / pharmacology*
  • Escherichia coli / drug effects
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Piperidines / blood
  • Piperidines / chemical synthesis*
  • Piperidines / pharmacology*
  • Protein Biosynthesis / drug effects*
  • Pseudomonas aeruginosa / drug effects*
  • Structure-Activity Relationship

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Diamines
  • Piperidines