[Precoce survey: a new self-assessment patient card for early detection and management of Parkinson disease fluctuations]

Rev Neurol (Paris). 2008 Apr;164(4):354-62. doi: 10.1016/j.neurol.2008.01.003. Epub 2008 Apr 3.
[Article in French]

Abstract

It has been known for more than 30 years that the efficiency of the dopaminergic treatments can wear off. Currently, motor fluctuations and especially non-motor fluctuations (dysautonomic, cognitive/psychiatric or sensory/pain) remain often underdiagnosed in the first years of treatment. The patient self-questionnaire used in this study has been developed and validated in the United States. Its French version has been tested in daily practice in a study with 938 Parkinson's patients followed-up by movement disorders specialists. Use of this self-assessment patient card has resulted in the detection of fluctuations in 49% of patients, considered nonfluctuating by neurologists after a clinical assessment. The impact of these fluctuations unknown at first is significant, since these motor and/or non motor symptoms are considered troublesome or perturbing for daily life activities by 70% of fluctuating patients. The investigators have recognized the usefulness of this self-assessment in order to detect fluctuations in 81% of fluctuating patients, which lead them to modify the treatment in 76% of them.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology
  • Antiparkinson Agents / therapeutic use
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Movement Disorders / diagnosis
  • Movement Disorders / etiology
  • Movement Disorders / physiopathology
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy*
  • Reproducibility of Results
  • Surveys and Questionnaires*

Substances

  • Antiparkinson Agents
  • Levodopa