The angiotensin converting enzyme insertion/deletion polymorphism and differences in fasting plasma glucose in Hindustani Surinamese, African Surinamese and ethnic Dutch: the population-based SUNSET-study

Irene G M van Valkengoed; Karien Stronks; Ines N Hahntow; Joost B L Hoekstra; Frits Holleman

doi:10.1016/j.diabres.2008.03.010

The angiotensin converting enzyme insertion/deletion polymorphism and differences in fasting plasma glucose in Hindustani Surinamese, African Surinamese and ethnic Dutch: the population-based SUNSET-study

Diabetes Res Clin Pract. 2008 Jul;81(1):e12-4. doi: 10.1016/j.diabres.2008.03.010. Epub 2008 Apr 24.

Authors

Irene G M van Valkengoed¹, Karien Stronks, Ines N Hahntow, Joost B L Hoekstra, Frits Holleman

Affiliation

¹ Department of Social Medicine, Academic Medical Centre, University of Amsterdam, J2-207 Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. I.G.vanValkengoed@amc.uva.nl

PMID: 18439702
DOI: 10.1016/j.diabres.2008.03.010

Abstract

We investigated the association between the angiotensin converting enzyme (ACE) insertion/deletion polymorphism and glycemic state. Diabetes mellitus, impaired fasting glucose and mean fasting glucose were not associated with genotype among Hindustani Surinamese, African Surinamese and Dutch participants. Our results cast (further) doubts on the association between ACE and glycemic state.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Africa / ethnology
Blood Glucose / metabolism*
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / enzymology*
Diabetes Mellitus, Type 2 / genetics
Fasting
Genotype
Humans
Middle Aged
Mutagenesis, Insertional*
Netherlands
Peptidyl-Dipeptidase A / deficiency
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Sequence Deletion*
Suriname / ethnology

Substances

Blood Glucose
Peptidyl-Dipeptidase A