Conjugation of ATIII-binding pentasaccharides to extend the half-life of proteins: long-acting insulin

ChemMedChem. 2008 Aug;3(8):1189-93. doi: 10.1002/cmdc.200800053.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antithrombin III / chemistry*
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Half-Life
  • Insulin, Long-Acting / blood
  • Insulin, Long-Acting / chemistry*
  • Insulin, Long-Acting / pharmacology*
  • Male
  • Models, Molecular
  • Molecular Sequence Data
  • Oligosaccharides / chemistry*
  • Protein Structure, Tertiary
  • Rats
  • Rats, Wistar

Substances

  • Insulin, Long-Acting
  • Oligosaccharides
  • Antithrombin III