The study analyses, first, the prevalence of risk factors of ischaemic heart disease among the male population of the city of Bishkek, aged 40-59 years (n = 5246) and, second, the efficacy of a preventive programme according to the development of risk factors in groups exposed to preventive measures of various intensity during 5 years. The prevalence of IHD risk factors in the given population was very high. In the group exposed to active preventive intervention a decrease in the prevalence of arterial hypertension, hypercholesterolaemia, smoking and low physical activity was registered after 5 years, compared to a group without active prevention.