Abstract
The enzyme inhibitory activity of a new group of 2-substituted pyrimido[4,5-b][1,4]benzothiazines on soybean 15-lipoxygenase (15-LO) was evaluated and compared with those of their 4-methyl analogs using ab initio calculations. The results of these studies showed that the lack of 4-methyl substituent in the pyrimido[4,5-b][1,4] benzothiazine molecules greatly reduces their 15-LO inhibitory activities.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Arachidonate 15-Lipoxygenase / chemistry
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology*
-
Glycine max / enzymology
-
Lipoxygenase Inhibitors*
-
Models, Molecular
-
Molecular Structure
-
Protein Conformation
-
Pyrimidines
-
Structure-Activity Relationship
-
Thiazines
Substances
-
Enzyme Inhibitors
-
Lipoxygenase Inhibitors
-
Pyrimidines
-
Thiazines
-
Arachidonate 15-Lipoxygenase