Collision-induced liquid secondary-ion mass spectra of oxytocin derivatives. A study of the influence of modifications in the disulfide bond on the adjacent peptide bond cleavage

J Malát; K Ubik; M Lebl

doi:10.1002/rcm.1290050704

Collision-induced liquid secondary-ion mass spectra of oxytocin derivatives. A study of the influence of modifications in the disulfide bond on the adjacent peptide bond cleavage

Rapid Commun Mass Spectrom. 1991 Jul;5(7):316-8. doi: 10.1002/rcm.1290050704.

Authors

J Malát¹, K Ubik, M Lebl

Affiliation

¹ Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.

PMID: 1841650
DOI: 10.1002/rcm.1290050704

Abstract

The influence of the inductive effect of modifications in the disulfide bridge in oxytocin analogs on the cleavage of the neighboring peptidic bond was studied. A correlation between the inductive constant of the group in the disulfide bridge and the particular fragment ion abundance was observed.

MeSH terms

Amino Acid Sequence
Disulfides / analysis*
Mass Spectrometry
Molecular Sequence Data
Oxytocin / analogs & derivatives*
Oxytocin / analysis*
Peptide Fragments / analysis

Substances

Disulfides
Peptide Fragments
Oxytocin