Multidrug-resistant viridans streptococcus (MDRVS) osteomyelitis of the mandible successfully treated with moxifloxacin

South Med J. 2008 May;101(5):539-40. doi: 10.1097/SMJ.0b013e3181684ee3.

Abstract

Multidrug-resistant viridans group streptococcus (MDRVS) strains have emerged as important pathogens. Treatment of MDRVS infections is problematic. The use of fluoroquinolones for treatment of MDRVS osteomyelitis has not been established. We present the first case of MDRVS osteomyelitis of the mandible successfully treated with sequential intravenous then oral moxifloxacin, and review the literature on the subject.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / therapeutic use*
  • Aza Compounds / administration & dosage
  • Aza Compounds / pharmacology
  • Aza Compounds / therapeutic use*
  • Debridement
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Fluoroquinolones
  • Humans
  • Mandibular Diseases / drug therapy*
  • Mandibular Diseases / microbiology*
  • Mandibular Diseases / surgery
  • Moxifloxacin
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology*
  • Osteomyelitis / surgery
  • Quinolines / administration & dosage
  • Quinolines / pharmacology
  • Quinolines / therapeutic use*
  • Streptococcal Infections / drug therapy*
  • Viridans Streptococci* / drug effects

Substances

  • Anti-Infective Agents
  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Moxifloxacin