Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages

J A Secrist 3rd; P A Crooks; J A Maddry; R C Reynolds; A S Rathore; M S Ahktar; J A Montgomery

Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages

Nucleic Acids Symp Ser. 1991:(24):5-8.

Authors

J A Secrist 3rd¹, P A Crooks, J A Maddry, R C Reynolds, A S Rathore, M S Ahktar, J A Montgomery

Affiliation

¹ Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255-5305.

PMID: 1841378

Abstract

The synthesis of building blocks for the preparation of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages is described. Coupling conditions for the conversion of several of these monomers to dimers are also described.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Dinucleoside Phosphates / chemical synthesis*
Indicators and Reagents
Molecular Structure
Oligonucleotides / chemical synthesis*
Sulfonamides*
Sulfonic Acids*
Thionucleotides*

Substances

Dinucleoside Phosphates
Indicators and Reagents
Oligonucleotides
Sulfonamides
Sulfonic Acids
Thionucleotides