Leukocytosis is linked to thrombosis at diagnosis, while JAK2 V617F mutation is associated with thrombosis during the course of essential thrombocythemia

Int J Hematol. 2008 May;87(4):446-448. doi: 10.1007/s12185-008-0080-9.

Authors

Kazuma Ohyashiki¹, Toru Kiguchi², Yoshikazu Ito², Hiroaki Fujimoto², Akihiko Gotoh², Tetsuzo Tauchi², Keisuke Miyazawa², Yukihiko Kimura², Junko H Ohyashiki³

Affiliations

¹ Hematology Division, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 169-0023, Japan. ohyashik@rr.iij4u.or.jp.
² Hematology Division, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 169-0023, Japan.
³ Intractable Immune System Diseases Research Center, Tokyo Medical University, Tokyo, Japan.

PMID: 18409076
DOI: 10.1007/s12185-008-0080-9

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Humans
Janus Kinase 2 / genetics
Janus Kinase 2 / metabolism*
Leukocytosis / complications
Leukocytosis / diagnosis*
Leukocytosis / enzymology*
Leukocytosis / genetics
Male
Middle Aged
Mutation / genetics
Phenylalanine / genetics
Phenylalanine / metabolism
Thrombocythemia, Essential / complications*
Thrombocythemia, Essential / enzymology*
Thrombocythemia, Essential / genetics
Thrombosis / complications
Thrombosis / diagnosis*
Thrombosis / enzymology*
Thrombosis / genetics
Valine / genetics
Valine / metabolism

Substances

Phenylalanine
Janus Kinase 2
Valine