Abstract
Five new dihydroxystyrene metabolites and six known compounds of the same structural class were isolated from an association of the sponges Poecillatra wondoensis and Jaspis sp., collected from Keomun Island, Korea. The structures of novel compounds were determined to be the sodium or N, N-dimethyl guanidinium salts of a dihydroxystyrene dimer (5) and two trimers (6, 7). Two dimers (10, 11) containing imidazole moieties were also identified on the basis of the results of combined spectroscopic analyses. Several compounds exhibited weak to moderate inhibitory effects against isocitrate lyase and sortase A enzymes derived from microorganisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoacyltransferases / antagonists & inhibitors*
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Animals
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Bacterial Proteins / antagonists & inhibitors*
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Cysteine Endopeptidases
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Humans
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Isocitrate Lyase / antagonists & inhibitors*
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Korea
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Microbial Sensitivity Tests
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Molecular Structure
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Porifera / chemistry*
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Styrenes / chemistry
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Styrenes / isolation & purification*
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Styrenes / pharmacology
Substances
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Bacterial Proteins
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Enzyme Inhibitors
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Styrenes
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Aminoacyltransferases
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sortase A
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Cysteine Endopeptidases
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Isocitrate Lyase