In this report, we describe computer-based design and production of occlusal splints. A research effort was undertaken to develop a process to eliminate the inherent variabilities associated with current splint-fabrication methods. The digital process provides quantitative control over articulation and splint design, and produces splints with continuously smooth occlusal surfaces. Stone casts are laser scanned, and custom software is used to articulate and design flat-plane and full-coverage splints with guidance ramps. Splints are produced by milling excess acrylic placed over stone casts. Clinically, digital splints reduce the average time needed for placement because intraoral equilibration is minimized.