Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats

Junko Yokota; Daisuke Takuma; Atsuhide Hamada; Masahide Onogawa; Saburo Yoshioka; Masahiko Kusunose; Mitsuhiko Miyamura; Shojiro Kyotani; Yutaka Nishioka

doi:10.1007/s11418-007-0195-y

Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats

J Nat Med. 2008 Jan;62(1):96-100. doi: 10.1007/s11418-007-0195-y. Epub 2007 Oct 2.

Authors

Junko Yokota¹, Daisuke Takuma, Atsuhide Hamada, Masahide Onogawa, Saburo Yoshioka, Masahiko Kusunose, Mitsuhiko Miyamura, Shojiro Kyotani, Yutaka Nishioka

Affiliation

¹ Japan Science and Technology Agency, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan. jm-yokotaj@kochi-u.ac.jp

PMID: 18404352
DOI: 10.1007/s11418-007-0195-y

Abstract

The effect of Eriobotrya japonica seed extract (ESE) prepared with 70% ethanol on gastric mucosal injury was investigated. Six experimental models with different action mechanisms were used for the evaluation. Three concentrations of ESE were prepared for each model. ESE administration was initiated 14 days before induction of gastric mucosal injury, and its effect was investigated. ESE inhibited formation of gastric mucosal injury.

MeSH terms

Animals
Chromatography, High Pressure Liquid
Disease Models, Animal
Dose-Response Relationship, Drug
Eriobotrya* / chemistry
Gastric Acid / metabolism
Gastric Juice / metabolism
Gastric Mucosa / drug effects*
Gastric Mucosa / metabolism
Gastric Mucosa / pathology
Gastrointestinal Agents / chemistry
Gastrointestinal Agents / pharmacology*
Gastrointestinal Agents / therapeutic use
Male
Mucus / metabolism
Plant Extracts / pharmacology
Protective Agents / chemistry
Protective Agents / pharmacology*
Protective Agents / therapeutic use
Rats
Rats, Wistar
Seeds*
Stomach Ulcer / metabolism
Stomach Ulcer / pathology
Stomach Ulcer / prevention & control*

Substances

Gastrointestinal Agents
Plant Extracts
Protective Agents