Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis

J Nat Med. 2008 Apr;62(2):232-5. doi: 10.1007/s11418-007-0218-8. Epub 2007 Dec 14.

Abstract

Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5 beta-tirucall-9(11),25-dien-3-one (1), squalene and a mixture of the phytosterols stigmasterol and beta-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H(37)Rv with a MIC of 64 microg/mL, while squalene and the sterol mixture have MICs of 100 and 128 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification
  • Antitubercular Agents / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / growth & development
  • Pandanaceae / chemistry*
  • Phytosterols / chemistry
  • Phytosterols / isolation & purification
  • Phytosterols / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry*
  • Sitosterols / chemistry
  • Sitosterols / isolation & purification
  • Sitosterols / pharmacology
  • Squalene / chemistry
  • Squalene / isolation & purification
  • Squalene / pharmacology
  • Stigmasterol / chemistry
  • Stigmasterol / isolation & purification
  • Stigmasterol / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • 24,24-dimethyltirucall-9(11),25-dien-3-one
  • Antitubercular Agents
  • Phytosterols
  • Plant Extracts
  • Sitosterols
  • Triterpenes
  • gamma-sitosterol
  • Squalene
  • Stigmasterol