Abstract
Ethyl acetate (EtOAc) extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin (1), citflavanone (2), erythrisenegalone (3), lonchocarpol A (4), liquiritigenin (5), and 8-prenyldaidzein (6), were isolated from the extract. Diprenylated flavanone 4 showed a notable antimalarial activity (IC(50); 1.6 microg/mL); however 1 and 3 did not show the activity, even though these compounds possessed prenylated substitution.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimalarials / chemistry
-
Antimalarials / isolation & purification
-
Antimalarials / pharmacology*
-
Cell Line
-
Drug Resistance, Multiple
-
Erythrina / chemistry*
-
Flavanones / chemistry
-
Flavanones / isolation & purification
-
Flavanones / pharmacology
-
Flavonoids / chemistry
-
Flavonoids / isolation & purification*
-
Flavonoids / pharmacology*
-
Humans
-
Isoflavones / chemistry
-
Isoflavones / isolation & purification
-
Isoflavones / pharmacology
-
Magnetic Resonance Spectroscopy
-
Parasitic Sensitivity Tests
-
Plant Bark / chemistry
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Plant Stems / chemistry
-
Plasmodium falciparum / drug effects*
-
Prenylation
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spectrophotometry, Ultraviolet
-
Thailand
Substances
-
8-prenyldaidzein
-
Antimalarials
-
Flavanones
-
Flavonoids
-
Isoflavones
-
Plant Extracts
-
citflavanone
-
erythrisenegalone
-
lupinifolin
-
senegalensin
-
liquiritigenin