Abstract
From the fruits of Phaleria macrocarpa, icariside C(3) (1), phalerin (2), and mangiferin (3) were isolated and their structures were identified on the basis of spectroscopic data. Icariside C(3) (1) showed a slow vasorelaxant activity against noradrenaline-induced contraction of isolated rat aorta. The structure of phalerin (2) was revised as 2,4',6-trihydroxy-4-methoxybenzophenone-2-O-beta-D-glucoside.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Aorta, Thoracic / physiology
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Benzophenones / chemistry
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Benzophenones / isolation & purification*
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Benzophenones / pharmacology
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Fruit / chemistry*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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In Vitro Techniques
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Male
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / physiology
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Norepinephrine / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rats
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Rats, Wistar
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Thymelaeaceae / chemistry*
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Vasoconstriction / drug effects
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Vasodilation / drug effects
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Vasodilator Agents / pharmacology
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Xanthones / chemistry
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Xanthones / isolation & purification*
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Xanthones / pharmacology
Substances
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2,4',6-trihydroxy-4-methoxybenzophenone-2-O-glucoside
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Benzophenones
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Glucosides
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Plant Extracts
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Sesquiterpenes
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Vasodilator Agents
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Xanthones
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icariside C3
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mangiferin
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Norepinephrine