Single microbead SELEX for efficient ssDNA aptamer generation against botulinum neurotoxin

Chem Commun (Camb). 2008 Apr 28:(16):1883-5. doi: 10.1039/b717936g. Epub 2008 Mar 18.

Abstract

An efficient and easy-to-execute single microbead SELEX approach is developed to generate high affinity ssDNA aptamers against botulinum neurotoxin.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Aptamers, Nucleotide / chemical synthesis*
  • Aptamers, Nucleotide / chemistry
  • Aptamers, Nucleotide / pharmacology*
  • Botulinum Toxins / antagonists & inhibitors*
  • Botulinum Toxins / chemistry
  • DNA, Single-Stranded / chemical synthesis*
  • DNA, Single-Stranded / chemistry
  • DNA, Single-Stranded / pharmacology*
  • Molecular Sequence Data
  • Neurotoxins / antagonists & inhibitors*
  • Neurotoxins / chemistry

Substances

  • Aptamers, Nucleotide
  • DNA, Single-Stranded
  • Neurotoxins
  • Botulinum Toxins