Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors

Bioorg Med Chem Lett. 2008 May 1;18(9):2948-51. doi: 10.1016/j.bmcl.2008.03.066. Epub 2008 Mar 27.

Abstract

A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / cytology
  • Aorta / drug effects*
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / pharmacology*
  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Drug Design*
  • Growth Inhibitors / chemical synthesis
  • Growth Inhibitors / pharmacology*
  • Inhibitory Concentration 50
  • Mitogen-Activated Protein Kinases / metabolism
  • Models, Chemical
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects*
  • Platelet-Derived Growth Factor / metabolism
  • Rats
  • Structure-Activity Relationship

Substances

  • Benzimidazoles
  • Growth Inhibitors
  • Platelet-Derived Growth Factor
  • Mitogen-Activated Protein Kinases