Synthesis and DNA binding ability of cyclam-amino acid conjugates

A Venkata Ramana; Michael Watkinson; Matthew H Todd

doi:10.1016/j.bmcl.2008.03.045

Synthesis and DNA binding ability of cyclam-amino acid conjugates

Bioorg Med Chem Lett. 2008 May 1;18(9):3007-10. doi: 10.1016/j.bmcl.2008.03.045. Epub 2008 Mar 20.

Authors

A Venkata Ramana¹, Michael Watkinson, Matthew H Todd

Affiliation

¹ School of Chemistry, University of Sydney, NSW 2006, Australia.

PMID: 18396400
DOI: 10.1016/j.bmcl.2008.03.045

Abstract

N-Substituted cyclam-amino acid conjugates have been synthesised both in solution and on the solid phase. The DNA binding affinity of these species has been studied: the nature of the amino acid strongly influences the change in melting temperature suggesting that simple cyclam-peptide conjugates could interact with DNA in a highly selective manner.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Amino Acids* / chemical synthesis
Amino Acids* / metabolism
Anti-HIV Agents / pharmacology*
Antineoplastic Agents / pharmacology*
Binding Sites
DNA / chemistry
DNA / metabolism*
Lactams, Macrocyclic* / chemical synthesis
Lactams, Macrocyclic* / metabolism
Models, Chemical
Molecular Sequence Data
Temperature

Substances

Amino Acids
Anti-HIV Agents
Antineoplastic Agents
Lactams, Macrocyclic
DNA