Obsessive-compulsive disorder (OCD) is a common comorbid condition in schizophrenia. The clinical implications of this comorbidity are uncertain. There is some evidence to suggest that schizophrenia with OCD (schizo-obsessive) has a poor prognosis, but the effect of OCD on schizophrenia symptom profile is unclear. Therefore, we studied the clinical profile of schizophrenic patients with and without comorbid OCD. Fifty consecutive patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for both schizophrenia and OCD and an equal number of schizophrenic patients without OCD were recruited over a period of 12 months from the clinical services of the National Institute of Mental Health and Neuro Sciences, Bangalore, India. Their clinical profile was systematically assessed and compared to detect significant differences, if any. Schizo-obsessive patients were more likely to have paranoid symptoms and first-rank symptoms of schizophrenia. They had lower anergia, higher depression scores, more comorbid personality disorders, and somewhat lesser disability. Significant correlations were observed between the Yale-Brown Obsessive-Compulsive Scale scores (including the Yale-Brown Obsessive-Compulsive Scale insight score) and schizophrenia symptom dimension scores. Our findings are concordant with the hypothesis that "schizo-obsessive" schizophrenia may be a distinct subtype with unique clinical characteristics, supporting the need for further research in this area.