The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function

Eur J Immunol. 2008 Apr;38(4):915-7. doi: 10.1002/eji.200738111.

Abstract

Stimulation of mouse CD4+ T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of Treg function. Stimulation of human CD4+ T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of Treg also induces Foxp3 expression and Treg function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic Treg.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Forkhead Transcription Factors / biosynthesis*
  • Humans
  • Mice
  • Models, Immunological
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism
  • Transforming Growth Factor beta / immunology*

Substances

  • Forkhead Transcription Factors
  • Receptors, Antigen, T-Cell
  • Transforming Growth Factor beta