[Oral contraceptives and cancer of the cervix uteri. Analysis of the strength of the association]

Rev Sanid Hig Publica (Madr). 1991 Jan-Feb;65(1):25-38.
[Article in Spanish]

Abstract

The power of the association between oral contraceptives and cervical cancer was analysed in all the papers published up to date. Fifty-three publications (from 48 studies) wer collected and graded as to quality using meta-analytical methods. Power achieved a figure of greater than or equal to 0.8 in a 24% of the associations studied. It showed a significant relationship with the existence of a significant relative risk of the oral contraceptives for cervical cancer, with the quotient between sample sizes of reference and index groups, and with the sample size of a study, although the relationship was not linear to these two latter variables. Power did not show any significant relationship to other variables related to the design of a study, or to the biases detected. Logistic regression analysis included as predictors of a power greater than or equal to 0,80 the existence of a significant relative risk and the use of adjusted relative risk.

Publication types

  • Comparative Study
  • English Abstract
  • Meta-Analysis

MeSH terms

  • Carcinoma / chemically induced*
  • Carcinoma in Situ / chemically induced*
  • Cohort Studies
  • Contraceptives, Oral / adverse effects*
  • Female
  • Humans
  • MEDLINE
  • Meta-Analysis as Topic
  • Regression Analysis
  • Uterine Cervical Dysplasia / chemically induced
  • Uterine Cervical Neoplasms / chemically induced*

Substances

  • Contraceptives, Oral