CD30-positive T-cell lymphoproliferative disorder of the oral mucosa--an indolent lesion: report of 4 cases

Int J Surg Pathol. 2008 Jul;16(3):286-90. doi: 10.1177/1066896907313755. Epub 2008 Apr 2.

Abstract

Four cases of CD30-positive T-cell lymphoproliferative disorder (CD30+ LPD) of the oral mucosa are described. This article aims to draw attention to this entity and to emphasize its usual benign clinical behavior despite its resemblance to T-cell lymphoma. All the patients were adults. Three of the lesions were on the dorsal surface of the tongue and 1 affected the buccal mucosa. All biopsies showed a dense lymphoid infiltrate composed of CD30+ atypical T cells with a polymorphous infiltrate in the background, which included eosinophils. In 1 case, monoclonal T-cell expansion was detected by molecular techniques. Three cases tested for Epstein-Barr virus were all negative. It is concluded that primary CD30+ T-cell LPD of the oral mucosa can be regarded as the oral counterpart of cutaneous CD30+ LPD such as lymphomatoid papulosis or anaplastic large cell lymphoma. Recognition of the condition is important to avoid overtreatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Gene Rearrangement, T-Lymphocyte / genetics
  • Humans
  • Immunohistochemistry
  • Ki-1 Antigen / metabolism*
  • Lymphoproliferative Disorders / genetics
  • Lymphoproliferative Disorders / metabolism
  • Lymphoproliferative Disorders / pathology*
  • Male
  • Middle Aged
  • Mouth Mucosa / immunology
  • Mouth Mucosa / metabolism
  • Mouth Mucosa / pathology*
  • Remission, Spontaneous
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / pathology*
  • Tongue

Substances

  • Ki-1 Antigen