Abstract
The Klebsiella pneumoniae carbapenemase (KPC) was detected in carbapenem-resistant isolates of Citrobacter freundii and Klebsiella oxytoca recovered from different patients in a Michigan hospital. Restriction analysis and hybridization with a KPC-specific probe showed the bla(KPC-2) genes of these two genera of the family Enterobacteriaceae are carried on a common plasmid.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Carbapenems / metabolism*
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Carbapenems / pharmacology
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Citrobacter freundii / drug effects
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Citrobacter freundii / enzymology*
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Citrobacter freundii / genetics
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Citrobacter freundii / isolation & purification
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Enterobacteriaceae Infections / microbiology
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Humans
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Klebsiella Infections / microbiology
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Klebsiella oxytoca / drug effects
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Klebsiella oxytoca / enzymology*
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Klebsiella oxytoca / genetics
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Klebsiella oxytoca / isolation & purification
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Klebsiella pneumoniae / enzymology*
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Microbial Sensitivity Tests
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Nucleic Acid Hybridization / methods
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Plasmids / genetics*
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Restriction Mapping
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Carbapenems
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beta-lactamase KPC-2
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beta-Lactamases